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dar boosted anti d hdfn case study dr chlo pass trainee clinical scientist transfusion science immunology scottish national blood transfusion service bbts annual conference 17th october 2013 haemolytic disease foetus newborn anaemia jaundice kernicterus hydrops fetalis transplacental passage maternal igg alloantibody causes opsonisation foetal red cells extravascular haemolysis fatality dropped significantly since introduction prophylactic anti d igg maternal history blood group a rhd negative o

the eurobloodpack ibts perspective authors neil beckman harry croxon presented behalf technical committee eurobloodpack purchasing group bbts components sig birminghan 2013 october 16 eurobloodpack purchasing group collaborators netherlands sanquin blood supply foundation irish blood transfusion service nhs blood transplant northern ireland blood transfusion service scottish national blood transfusion service welsh blood service plus other future beneficiaries bbts components sig birminghan 2013

sharon gale poole hospital nhs foundation trust 518 beds 2012 major incident hospital high risk obstetrics gynae neonatal specialties dorset cancer centre cardiac arterial renal specialties contracted supply 5 community hospitals 1 private hospital blood components 30 000 g s samples per year bsms high user red cells ditched maximum surgical blood ordering schedule msbos promoted two sample system electronic issue ei converted routine surgical requests supply demand exceptions antibody patients

post transfusion infections really blood su brailsford consultant epidemiology health protection bbts sig birmingham 2013 national blood service bacterial v viral infections bacterial report symptoms outcome reported hospital discharge hours days usually acute viral may years may recognised serious morbidity fatal may clear become chronic rarely national blood service nhsbt investigations usually receive about 100 reports possible bacterial tti year 20 25 possible post transfusion infections bac

increased red cell turnover a line cd22 deficient mice caused gpi1c a model hereditary haemolytic anaemia dr jennifer walker mrc laboratory molecular biology cambridge institute medical research cd22 a b cell inhibitory receptor sia2 6gal cd22 b cell receptor complex syk lyn p shp 1 cellular activation doody et al science 1995 powell et al jbc 1995 nitschke et al curr biol 1997 smith et al jem 1998 cornall et al immunity 1998 autoimmune haemolytic anaemia aiha accelerated rbc clearance haemolysi